Panelists offer a realistic outlook for FFF, with miniaturization and emerging application areas seen as future directions.
Susanne Boye
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Susanne Boye graduated with a degree in biochemical engineering from the University of Applied Sciences Dresden (Germany) in 2006. She completed her doctoral thesis on “Modern fractionation techniques for branched polymers” at the Technical University of Dresden and the IPF. Since then, she has been a member of the Polymer Separation Group and established the AF4 technique at the IPF, where she now leads the FFF labs and serves as deputy head of the Department of Advanced Macromolecular Structure Analysis. Her work focuses on the application and development of AF4 with multidetection systems. Boye is particularly interested in the physicochemical and in-depth characterization of polymer–protein conjugates, complex synthetic and natural (bio)nanostructures, and molecular interactions. She has specific expertise in the conformational analysis of biomacromolecules.
She has 18 years of work experience with FFF.
Articles by Susanne Boye
Experts assess whether coupling with detectors such as MALS, Raman, and ICP-MS has elevated FFF from exploratory research to a decision-making tool.
Panelists agree that a shortage of trained users underpins all other barriers to FFF becoming a validated routine tool in industrial settings.
Experts examine how automation, software harmonization, and AI-assisted data analysis could lower barriers to FFF adoption and support routine use.
Panelists identify biopharma and environmental nanoplastics analysis as the most significant emerging drivers of FFF development.
From hand-built channels to commercial instruments, experts discuss the instrumentation, applications, and theory that have shaped FFF.
Field-flow fractionation (FFF), and, in particular, asymmetrical flow field-flow fractionation (AF4), is transitioning from a specialized separation technique into an application-driven analytical platform. From the perspective of the Young Scientists of FFF, we describe how advances in inline detection, data analysis, and validation are expanding AF4’s capacity to deliver size-resolved structural and compositional insights into complex systems. We highlight how this evolution enables more reliable characterization of heterogeneous and dynamically assembled materials across disciplines. We argue that realizing this potential will require deliberate choices (by the community, instrument developers, and end users) to move AF4 from niche expert knowledge to broadly trusted analytical practice.
The authors present their motivation for establishing the Young Scientists of FFF (YSFFF) initiative within the FFF community.
In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.
LCGC Europe
This information is supplementary to the article “The Effect of Carrier Liquid Composition on the Molecular Properties of Caseinate Solutions Studied by AF4” that was published in the March 2020 issue of LCGC Europe.
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