Wen Jiang | Authors


Determination of Psilocin and Psilocybin in Magic Mushrooms Using iHILIC®-Fusion and MS

Hallucinogenic mushrooms, known as magic mushrooms, contain psychoactive compounds such as psilocin and psilocybin (Figure 1). This hallucinogenic effect means they are constantly offered on the black market. Therefore, the reliable quantification of these compounds is a particularly important task for forensic analysis because their results have a significant impact on the judgement passed by the courts.

Analysis of Phospholipid Classes by iHILIC®-Fusion

Phospholipids (PLs) are the major components of cellular membranes. They are important for the functionality of membrane proteins or serve as precursors for second messengers. Several studies reveal the role of PL alterations in various diseases such as cancer (1). Therefore, it is crucial to identify and quantify PLs in complex biological samples for lipidomic studies and clinical research.

Analysis of Organophosphates in Lithium Ion Battery Electrolytes by HILIC–ESI-MS

New separation techniques for the analysis of polar and ionic analytes have aroused great interest in the field of metabolomics and environmental investigation in the past two decades. Hydrophilic interaction liquid chromatography (HILIC) is a promising tool to address this challenge. HILIC separation is based on the polarity of analytes, which generally show stronger retention with increasing polarity according to the HILIC separation mechanism. Furthermore, the high content of organic solvent in the mobile phase leads to good ionization properties in the electrospray ionization (ESI), and consequently enhances the detection sensitivity by hyphenated mass spectrometry (MS) detector.

Direct Analysis of Amino Acids by HILIC–ESI-MS

Hydrophilic interaction liquid chromatography coupled to electrospray ionization mass spectrometry (HILIC–ESI-MS) has been established as a method to separate and quantify polar and ionic analytes in a direct way for two decades. HILIC separation is based on the polarity of analytes, so the more polar analytes have stronger retention on a HILIC column.