Wesley W. Barnhart is a principal scientist in the Synthetic Separations group within the Research and Development department at Amgen. His expertise is focused on analytical and preparative separations of achiral and chiral small molecules, oligonucleotides, and mass-directed purification of microgram levels of pharmaceutical compounds.
In this month's edition of LC Troubleshooting, Dwight Stoll and his fellow researchers discuss both the benefits (improved peak shape/loading) and challenges (excessive interaction) associated with charge-doped reversed-phase (RP) columns for both analytical and preparative separations.
Published: May 13th 2025 | Updated:
