YMC Europe GmbH

Analysis of denatured and non-denatured siRNA by use of the bioinert YMC-Accura Triart Bio C18 column in IP-RP mode and the BioPro IEX QF column in AEX mode.

mRNA coupled to EGFP (enhanced green fluorescent protein) is analyzed using a widepore YMC-Accura Triart Bio C4 RP column as well as a non-porous BioPro IEX QF column.

Molnupiravir, which is a prodrug, and its active agent β-d-N4-hydroxycytidine can be separated by using a YMC-Triart C18 UHPLC column and a MS-compatible mobile phase.

Learn about the charge variant analysis of monoclonal antibodies (mAbs) by HPLC. Various aspects are covered including the use of the type of column, buffer selection and gradient types. Furthermore, how IEX can be directly coupled to mass spectrometry and what parameters need to be considered.

Wednesday and Thursday, June 29 and 30, 2022 Day 1: 8:00am – 11:15am EDT Day 2: 8:00am – 11:15am EDT Learn about the latest novel analytical techniques and workflows that help analysts obtain the results they are looking for in “real world” situations involving small molecules in the pharmaceutical sector and analysts analyzing small molecules in the environment.

The active progestin enantiomer levonorgestrel can reliably be separated from the inactive dextronorgestrel using YMC’s immobilised Chiral Art Cellulose-SC column.

A YMC-Triart C18 and a YMC-Triart SIL column were used in RP and NP mode, respectively, for the analysis of four different phosphoramidites.

The recently introduced 1 mm YMC-Triart C18 UHPLC column was used for the high sensitivity LC–MS screening of six antineoplastic drugs.

A YMC-Triart C18 and a YMC-Triart SIL column were used in RP and NP mode, respectively, for the analysis of four different phosphoramidites.

Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column, ensuring symmetric peaks, high sensitivity, and no carryover effects.

The separation of three cell-penetrating peptides (CPPs) was performed using a YMC-Triart C18 UHPLC column, providing sharp peaks for a fast analysis in under 4 min.

Twenty-eight PFAS in human serum were analyzed using a YMC-Triart C18 column. An automated SPE system was coupled to an online SPE column-switching LC–MS/MS method.

Four hydrophilic dipeptides were separated with excellent resolution using a YMC-Triart SIL column. Even structurally similar dipeptides were separated in under 4 min.

The UHPLC analysis of four cyclic peptides is shown. Based on the hydrophobicity of the peptides, a YMC-Triart Bio C4 UHPLC column was chosen for this application.

The analysis of FMOC-derivatized glyphosate and AMPA in water samples was performed using a YMC-Triart C18 UHPLC column at an elevated pH of 9.5.

The analysis of FMOC-derivatized (fluorenmethyloxycarbonyl) glyphosate and AMPA according to DIN ISO 16308 is performed using a YMC-Triart C18 UHPLC column at pH 9.5.

Six nitrosamines are separated using a YMC-Triart C18 UHPLC column. This is challenging due to the commonly observed small peaks thanks to low impurity concentrations.

Six nitrosamines are separated using a YMC-Triart C18 UHPLC column. This is challenging due to the commonly observed small peaks thanks to low impurity concentrations.

A fast separation of remdesivir and its active metabolite GS-441524 for the treatment of COVID-19 is obtained in only 3 minutes using a YMC-Triart C18 UHPLC column.

Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

In reference to the Japanese Pharmacopeia, YMC-Triart Bio C18 was used to analyze the peptide leuprorelin (GnRH analogue) and separate it from its degradation products.

In this application note, YMC’s dedicated SEC column for antibodies, YMC-SEC MAB, has been used to develop a method for bevacizumab using MALLS detection.

Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column ensuring symmetric peaks, high sensitivity, and no carryover effects.

The antibody-drug conjugate was separated from its aggregates and fragments in only one run using a YMC-SEC MAB column and varying mobile phases.

In this application note, the DAR of the SigmaMAb ADC-mimic was determined using YMC’s BioPro HIC BF column and a nanospray ionization mass spectrometer.

Mipomersen (Kynamro®) is used as a model for the analysis of antisense oligonucleotides (ASOs) using LC-HRMS. The YMC-Triart C8 metal-free column used is an excellent choice for oligonucleotides.