This application note demonstrates how the use of DCM in particular had a dramatic effect on the separation and afforded conditions that could be further adapted to a preparative scale application.
Wednesday and Thursday, June 29 and 30, 2022 Day 1: 8:00am – 11:15am EDT Day 2: 8:00am – 11:15am EDT Learn about the latest novel analytical techniques and workflows that help analysts obtain the results they are looking for in “real world” situations involving small molecules in the pharmaceutical sector and analysts analyzing small molecules in the environment.
This technical article outlines the analysis of long-chain oligonucleotides utilizing a simple eluent containing acetonitrile with a relatively low level of salt and no ion-pair reagent.
The SI-36 4D does not require organic solvent to achieve the separation. Gradient conditions and phosphate ions are eluted within 15 minutes, so analysis time is short.