The Application Notebook
June 01, 2014
General
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The unique surface chemistry of the Flare diamond core-shell column combines ionic and hydrophobic separation mechanisms to effectively retain a variety of chemical species in a single run.
June 01, 2014
Food & Beverage
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Modified starches are important materials used in many applications including foodstuffs.
June 01, 2014
Medical/Biological
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High resolution time-of-flight mass spectrometry was used for comprehensive profiling of tobacco plant extracts.
June 01, 2014
Pharmaceutical/Drug Discovery
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Poly(lactic-co-glycolic acid) (PLGA) is a copolymer based on glycolic acid and lactic acid. The two monomer units are linked together by ester linkages and form linear polyester chains.
June 01, 2014
Pharmaceutical/Drug Discovery
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Steroids represent a chemically distinct class of hormones with wide-ranging biological functions. Synthetic derivatives of endogenous steroid prototypes are used medically in birth control and in the treatment of asthma, arthritis, inflammation, and osteoporosis.
June 01, 2014
Food & Beverage
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The dioxin family consists of 210 compounds, of which 17 contain the 2,3,7,8 pattern of chlorination.
June 01, 2014
General
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Natural and synthetic phenolic compounds have been used in a wide range of applications, from antiseptics and fungicides to food additives.
June 01, 2014
Environmental
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Pharmaceutical and personal care products (PPCPs) are products used for personal health or cosmetic reasons.
June 01, 2014
General
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In mass spectrometry instrumentation, the sensitivity and resolution of the instrument is often limited by the detector.
June 01, 2014
Medical/Biological
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Monoclonal antibodies (mAbs) form a major class of biologics and recently biosimilars and biobetters are being added to the growing inventory of therapeutics.
June 01, 2014
Medical/Biological
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We have previously shown the ability of a novel stationary phase to separate 55 amino acids without derivatization (LCGC 32(3), 211 [2014]).
June 01, 2014
Pharmaceutical/Drug Discovery
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A purified polyclonal antibody (IgG) is separated and fully characterized using the Viscotek SEC-MALS 20, allowing calculation of molecular weight and radius of gyration (Rg).
June 01, 2014
Chiral
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Chiral separations of multi-component natural product mixtures comprised of enantiomers, diastereomers, and unrelated molecules are often difficult to resolve in a single isocratic method.
June 01, 2014
Environmental
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This application describes a solid phase extraction (SPE) method for EPA method 8141B analytes, including organophosphorus compounds, and triazine herbicides in water.
June 01, 2014
Pharmaceutical/Drug Discovery
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Alprostadil (Prostaglandin E1) is a drug that has vasodilation properties and is used to treat erectile dysfunction and other medical conditions.
June 01, 2014
Medical/Biological
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Hydrophilic interaction liquid chromatography (HILIC) is one of the fastest growing modes of separation, in which any polar chromatographic surface can be used.
June 01, 2014
Food & Beverage
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Two species of spearmint oil (mentha spicata and mentha gracilis) are cultivated in the United States.
June 01, 2014
Pharmaceutical/Drug Discovery
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Pain management LC analyses can be difficult to optimize due to the limited selectivity of C18 and phenyl-hexyl phases.
June 01, 2014
Food & Beverage
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Hydrophilic interaction chromatography (HILIC) provides an alternative approach for the separation of highly polar substances.
June 01, 2014
Pharmaceutical/Drug Discovery
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A novel method for drug antibody ratio determinations based on SEC-MALS in conjunction with UV absorption and differential refractive index detection.
June 01, 2014
Food & Beverage
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QuEChERS is a quick-easy-cheap-effective-rugged-safe extraction method developed in 2003 for the extraction of pesticide residues in agricultural commodities (1,2).
June 01, 2014
Food & Beverage
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This application note demonstrates how comprehensive 2D-LC can be used to resolve the complex mixture of hydrophilic phenols found in virgin olive oil and investigates differences in the phenol composition of several olive oils.
June 01, 2014
Pharmaceutical/Drug Discovery
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Selectivity is the most powerful tool to optimize separations in HPLC. This parameter is changed by using different bonded phases, including C18, polar embedded, phenyl bonded phases and perflorophenyl, or by changing the mobile phase. In this work, 4.6 ? 50 mm Poroshell 120 columns are used to quickly evaluate method development choices for the analysis of non-steroidal anti-inflammatory drugs (NSAIDS).
June 01, 2014
Medical/Biological
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A new fused-core particle designed specifically for the separation of proteins and monoclonal antibodies with 3.4 ?m particle size and a thin 0.2 ?m porous shell demonstrates high resolution of the heavy and light chain fragments of IgG1.
June 01, 2014
Issue PDF
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Click the title above to open the LCGC North America June 2014 Application Notebook, Vol 32 No s6, in an interactive PDF format.