Determination of Ephedra Alkaloids and Synephrine in Dietary Supplements via Strong Cation‑Exchange SPE and LC–MS/MS Detection
December 01, 2017
Ephedra alkaloids are phenethylamines that occur naturally in plants, including the herb Ma Huang used in traditional Chinese medicine. Ephedra alkaloids are potent CNS stimulants and also have a sympathomimetic effect on the peripheral nervous system. The aim of this study was to develop a multi-analyte procedure for the extraction, cleanup, and quantification of the ephedra alkaloids in functional foods and natural products. High capacity strong cation-exchange SPE cartridges were used for the isolation of ephedrine, pseudoephedrine, norephedrine, norpsuedoephedrine, methylephedrine, and synephrine from dietary supplements.