The Application Notebook-12-01-2018

The Application Notebook

Analysis of Fentanyl and Its Analogues in Human Urine by LC–MS/MS

December 01, 2018

Medical Biological

36

12

Abuse of synthetic opioid prescription painkillers such as fentanyl, along with a rapidly growing list of illicit analogues, is a significant public health problem. In this study, we developed a simple dilute-and-shoot method that provides a fast 3.5-min analysis of fentanyl and related compounds (norfentanyl, acetyl fentanyl, alfentanil, butyryl fentanyl, carfentanil, remifentanil, and sufentanil) in human urine by LC–MS/MS using a Raptor Biphenyl column.

Determination of the Molar Mass Distribution of Phenol Formaldehyde Resins Using GPC

December 01, 2018

General

36

12

Phenol formaldehyde resins (PFR) are used in various industrial products because of their versatile properties. Thermoplastic and thermo-reactive resin types differ in the degree of remaining reactive groups and their molar mass distribution (MMD). We compared the MMDs of two phenolic resins by gel permeation chromatography (GPC).

Determination of Pharmaceuticals from Serum

December 01, 2018

Pharmaceutical/Drug Discovery

36

12

This application note describes the determination of pharmaceuticals from serum using solid-phase extraction (SPE) with the hydrophilic-lipophilic balanced SPE phase CHROMABOND® HLB for analyte enrichment and for sample cleanup. The eluates from SPE are finally analyzed by HPLC–MS/MS on a NUCLEOSHELL® PFP core–shell phase.