LCGC Europe
May 20, 2016
Features
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Carotenoids are a class of natural pigments, widely distributed in vegetables and fruits. A comprehensive LC×LC method, based on the use of a cyano and an octodecylsilica column, placed in the first and second dimension, respectively, was applied to evaluate carotenoid composition and stability in selected overripe fruits representing the waste generated by a local food market.
May 20, 2016
Columns
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Understanding how liquid chromatography pumps operate can help streamline solving pump problems.
May 20, 2016
Columns
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29
John Hinshaw presents his annual review of new developments in the field of gas chromatography (GC) seen at Pittcon and other venues in the past year.
May 20, 2016
Columns
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The interface between the two separation dimensions is a key element of any comprehensive two‑dimensional liquid chromatography (LC×LC) system. LC×LC has typically been implemented by using one or more switching valves, equipped with either sampling loops or trap column(s). Temperature manipulation is a relatively unexplored yet promising route towards non-valve-based LC×LC. The fairly recent emergence of thermal modulation has provided a less conventional method for performing LC×LC separations. This article illustrates the variety of commonly used modulators, paying specific attention to focusing modulators.
May 20, 2016
Events
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The International Symposium on GPC/SEC and Related Techniques will be held at the Novotel in Amsterdam, Netherlands from 27–29 September 2016.
May 01, 2016
Issue PDF
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Click the title above to open the LCGC Europe May 2016 regular issue, Vol 29, No 5, in an interactive PDF format.
April 19, 2016
Cover Story
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Appropriate analytical methods are required to evaluate the presence, metabolism, degradation, and removal of specific compounds in complex mixtures. There is an increasing demand to analyze samples with a wide range of polarities in a variety of applications, including environmental analysis, biomarker discovery, and proteomics. Multiple analyses on complementary columns are often needed to cover the separation of all compounds with a large difference in polarity. This article describes a generic method involving an ultrahigh-pressure liquid chromatography (UHPLC) system equipped with two external switching valves to connect hydrophilic interaction liquid chromatography (HILIC) and reversed-phase LC columns in series for the sequential analysis of polar and apolar compounds. The method was successfully applied to separate 32 pharmaceutical compounds with a wide range of polarities, which could be useful for analyzing pharmaceutical compounds in the environment.