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LCGC Europe-07-01-2013

LCGC Europe

A New Method for Quality by Design Robust Optimization in Liquid Chromatography

July 01, 2013

Cover Story

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A new method to optimize liquid chromatography (LC) methods using a Quality by Design (QbD) approach is presented. This method is based on the use of design of experiments (DOE) and independent component analysis (ICA) to accurately estimate the modeled responses (that is, the retention times at the beginning, the apex, and the end) of each peak, even for coeluted peaks. This method was applied to the optimization of the separation of nine compounds in a mixture, yielding the design space and the demonstration of robustness of the method.

How Complete Are Your Chromatographic Data? Part 2

July 01, 2013

Questions of Quality

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The concluding part of the article from last month's "Question of Quality" on what "complete data" actually means in practice.

The Essence of Modern HPLC: Advantages, Limitations, Fundamentals, and Opportunities

July 01, 2013

Perspectives in Modern HPLC

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The reasons that make HPLC so ubiquitous; the fundamentals on how we conduct HPLC separations; and a few opportunities with far-reaching impacts in life sciences for separation scientists are discussed in this article.

Vol 26 No 7 LCGC Europe July 2013 Regular Issue PDF

July 01, 2013

Issue PDF

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Click the title above to open the LCGC Europe July 2013 regular issue, Vol 26 No 7, in an interactive PDF format.