LCGC Europe-12-01-2008

LCGC Europe

A Hydrophilic Interaction Chromatography Method for the Purity Analysis of Cytosine

December 01, 2008

Cover Story



Cytosine (chemical name 4-amino-2-hydroxypyrimidine) is a pyrimidine derivative with a hetereocyclic aromatic ring and two substituents (amine and keto groups) attached and is a polar compound of significant biological and pharmaceutical interest. In response to the intended use of bulk cytosine as a raw material in pharmaceutical manufacturing, a method for the determination of the purity of cytosine was developed.