October 2025

The aim of this article is to provide a validated and optimized CIC-based method for accurate measurement of total fluorine in materials with polymeric PFAS content in the low-ppm range, which could be used in the consumer electronics and potentially other industries. This, in turn, can aid companies in tracking and mitigating PFAS ahead of regulations.

Liquid chromatography (LC) is an incredibly powerful analytical tool that can be used to characterize materials across an astonishingly wide array of applications, ranging from 1 megaDalton polystyrenes to small genotoxic impurities of concern in pharmaceutical manufacturing. However, with this power also comes with a lot of detail related to successful operation of an LC instrument and analysis of the data it produces. This can be challenging when onboarding new LC users—how do we train someone new, where do we start, and which resources are best? In this installment, I will highlight ten high priority topics that every new user should be familiar with, no matter the training mechanism.