February 2021

Recent advances in stationary phases for hydrophobic interaction chromatography (HIC) permit HIC–MS analysis of intact antibodies and other proteins using direct flow to the mass spectrometer.

Mixed-mode chromatography columns are on the rise. We review recent fundamental research, stationary phase development and design, and areas of application.

Liquid chromatography (LC) pumps produce mobile-phase streams with small short-term variations in mobile phase composition. We explain the origin of these variations and their effects on chromatographic performance.

Paul Haddad and Erik L. Regalado are the winners of the 14th annual LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, respectively. We review their achievements.

By moving from GC–MS to GC–MS/MS, you can have both universal and selective detection along with low detection limits. Here’s how it works.

A method is described using a triple quadrupole LC–MS instrument with isotopic dilution to obtain the highest accuracy and confidence for analysis of per- and polyfluoroalkyl substances (PFAS) in water. Excellent method spike recoveries and robustness were found in wastewater.

The COVID-19 vaccine, and the speed at which it was developed, is the medical breakthrough of our lifetimes.