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LCGC North America-01-01-2020
LCGC North America
Vol 38 No 1 LCGC North America January 2020 Regular Issue PDF
January 01, 2020
LCGC North America, January 2020
38
1
Click the title above to open the LCGC North America January 2020 issue, Volume 38, Number 1, in an interactive PDF format.
Effects of Buffer Capacity in Reversed-Phase Liquid Chromatography, Part I: Relationship Between the Sample- and Mobile-Phase Buffers
January 01, 2020
LC Troubleshooting
38
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We return to the important topic of buffers, this time focusing on what happens when there is a mismatch between the mobile-phase buffer pH and the pH that the sample is buffered at.
A Review of Recent Developments in Analytical Characterization of Glycosylation in Therapeutic Proteins
January 01, 2020
Focus on Biopharmaceutical Analysis
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Advanced separation and mass spectrometry methods enable comprehensive profiling of the inherent glycan heterogeneities of protein therapeutics. In particular, reversed-phase HPLC–based multiattribute methods (MAMs) provide a wealth of information, and other techniques, such as HILIC and CE-MS, also continue to evolve.
The Current Landscape of Data Integrity
January 01, 2020
Focus on Data Handling
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A look at how data integrity requirements and the focus of data integrity have changed over the past five years.
Technical Challenges Encountered During Chromatographic Method Transfers to Pharmaceutical Manufacturing Sites
January 01, 2020
Peer-Reviewed Article
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Drug substance development requires a complex range of analytical methods, presenting a challenge to analytical chemists to reliably transfer and execute these fit-for-purpose methods to external manufacturing sites. Here, we provide guidelines to follow, and share examples of realworld problems and the strategies used to remedy them.