LCGC North America
January 01, 2020
LCGC North America, January 2020
38
1
Click the title above to open the LCGC North America January 2020 issue, Volume 38, Number 1, in an interactive PDF format.
January 01, 2020
LC Troubleshooting
38
1
We return to the important topic of buffers, this time focusing on what happens when there is a mismatch between the mobile-phase buffer pH and the pH that the sample is buffered at.
January 01, 2020
Focus on Biopharmaceutical Analysis
38
1
Advanced separation and mass spectrometry methods enable comprehensive profiling of the inherent glycan heterogeneities of protein therapeutics. In particular, reversed-phase HPLC–based multiattribute methods (MAMs) provide a wealth of information, and other techniques, such as HILIC and CE-MS, also continue to evolve.
January 01, 2020
Focus on Data Handling
38
1
A look at how data integrity requirements and the focus of data integrity have changed over the past five years.
January 01, 2020
Peer-Reviewed Article
38
1
Drug substance development requires a complex range of analytical methods, presenting a challenge to analytical chemists to reliably transfer and execute these fit-for-purpose methods to external manufacturing sites. Here, we provide guidelines to follow, and share examples of realworld problems and the strategies used to remedy them.