LCGC North America-06-01-2015
LCGC North America
Separation Science in Drug Development, Part I: High-Throughput Purification
June 01, 2015
Perspectives in Modern HPLC
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This installment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery.
Current State of Superficially Porous Particle Technology in Liquid Chromatography
June 01, 2015
Column Watch
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The use of superficially porous particles in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent in recent years. Over the course of the past decade most major manufacturers have built column lines around the technology.
Internal Standard Calibration Problems
June 01, 2015
LC Troubleshooting
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Readers' questions regarding problems related to internal standard calibration of liquid chromatography methods are addressed.
App of the Month: HPLC Troubleshooting
June 01, 2015
LCGC App of the Month
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The HPLC Troubleshooting app is designed to help beginner HPLC users with HPLC troubleshooting.
Analysis of Peptide Mixtures for Proteomics Research Using LC–ESI-MS with a Simple Microgradient Device
June 01, 2015
Peer-Reviewed Article
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This work presents an on-line combination of a simple microgradient device for reversed-phase liquid chromatography (LC) and electrospray ionization (ESI) tandem mass spectrometry (MS-MS).
Single-Cell MS and High-Spatial-Resolution MS Imaging Under Ambient Conditions Using a Novel Sampling Device
June 01, 2015
MS–The Practical Art
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We have developed a miniaturized, multifunctional device, called the "Single-Probe," that is capable of probing small targets and of sampling and ionizing molecular species.
GC Temperature Programming—10 Things You Absolutely Need to Know
June 01, 2015
The Essentials
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Temperature affects not only retention but also relative retention in gas chromatography (GC) and therefore, when we change temperature, we also change the selectivity of the separation. This is true as we alter the isothermal separation temperature, but also as we change the slope of the temperature program gradient.
Caroline West, LCGC’s 2015 Emerging Leader Award Winner, Focuses on the Fundamentals of Selectivity
June 01, 2015
Featured Interview
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Caroline West, the winner of the 2015 LCGC Emerging Leader in Chromatography award, has a diverse set of scientific interests-in high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC), hydrophilic-interaction chromatography (HILIC), and enantioselective separations-but all are primarily focused on the fundamentals of chromatographic selectivity.
Vol 33 No 6 LCGC North America June 2015 Regular Issue PDF
June 01, 2015
Issue PDF
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Click the title above to open the LCGC North America June 2015 regular issue, Vol 33 No 6, in an interactive PDF format.