LCGC North America-07-01-2005

The authors explain why sample diluent is more than just a solubilizing agent and describe a systematic process for diluent selection when developing an HPLC assay of an active pharmaceeutical ingredient.

Applied Biosystems, MDS Sciex, and Dionex Corporation form alliance

There is a great deal of confusion floating about when it comes to selecting gas mixtures for analytical applications. Questions such as "How is the gas certified?," "What standard should I use?," and "What level of uncertainty is acceptable?" are common concerns heard among those tasked with specifying and using mixtures. In addition, the uncertainty regarding terminology, measurement, safety, and storage can make specifying mixtures a true source of headaches and hassles for any lab manager. The following article provides answers to questions about gas mixtures.

Almost 40 years have passed since the concept of capillary electrophoresis (CE) was described by Hjertén (1) in 1967. It emerged as a viable analytical technique after the pioneering work of Jorgenson (2) in the early 1980s, and commercial instruments were first introduced at the end of that decade. It is appropriate at this time to survey the history of CE and to judge its success in the world of analytical instrumentation.

In this month's "LC Troubleshooting," we look at two questions submitted by readers that relate to mobile phase.

The authors review the latest technologies in MPT sample preparation used in study of genomics, proteomics, and metabolomics.