LCGC North America-09-01-20

Using the flame ionization detector (FID) as an example, we explain how the detector in a GC system generates a signal and how it is processed into chromatograms, and explore modern aspects of storing and processing digital data.

The topic of chromatographic integration and data interpretation raises a lot of questions about data integrity. Is it acceptable to integrate data? What are the limits?

A critical part of troubleshooting is understanding how the system should behave so that irregular behavior can be spotted. The more rules we know, the easier troubleshooting becomes. Learning these six rules is a great place to start.

In many applications, LC–MS approaches using HILIC, SFC, SEC, IEC, and HIC offer advantages over conventional reversed-phase LC–MS. The examples presented here should inspire you to consider these options for your analyses.

The traditional bonding techniques used to manufacture silica-particle-based HPLC stationary phases provide many benefits, but can emerging technologies tackle unmet needs? We assess current approaches and the potential for improvements.

Environmental laboratories with high sample throughput often wish to analyze PCDD/Fs and PCBs in separate fractions. The cleanup method described here results in complete separation, and offers an alternative to fully manual or fully automated cleanup.