LCGC North America-09-01-20

From Detector to Decision: How Does the GC Instrument Generate Your Data?

September 01, 2020

GC Connections

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Using the flame ionization detector (FID) as an example, we explain how the detector in a GC system generates a signal and how it is processed into chromatograms, and explore modern aspects of storing and processing digital data.

The Question of Chromatographic Integration in Data Integrity

September 01, 2020

Focus on Data Handling

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The topic of chromatographic integration and data interpretation raises a lot of questions about data integrity. Is it acceptable to integrate data? What are the limits?

Rules of Thumb for Reversed-Phase LC: What’s In Your Chromatographic Mind?

September 01, 2020

LC Troubleshooting

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A critical part of troubleshooting is understanding how the system should behave so that irregular behavior can be spotted. The more rules we know, the easier troubleshooting becomes. Learning these six rules is a great place to start.

Not (Only) Reversed-Phase LC–MS: Alternative LC–MS Approaches

September 01, 2020

Peer-Reviewed

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In many applications, LC–MS approaches using HILIC, SFC, SEC, IEC, and HIC offer advantages over conventional reversed-phase LC–MS. The examples presented here should inspire you to consider these options for your analyses.

What Is on Your HPLC Particle? A Look at Stationary Phase Chemistry Synthesis

September 01, 2020

Column Watch

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The traditional bonding techniques used to manufacture silica-particle-based HPLC stationary phases provide many benefits, but can emerging technologies tackle unmet needs? We assess current approaches and the potential for improvements.

Semi-Automated Cleanup of Persistent Organic Pollutants in Environmental Samples—Complete Separation of PCDD/Fs and PCBs for Extracts in Toluene

September 01, 2020

Focus on Environmental Analysis

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Environmental laboratories with high sample throughput often wish to analyze PCDD/Fs and PCBs in separate fractions. The cleanup method described here results in complete separation, and offers an alternative to fully manual or fully automated cleanup.