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In this article the authors describe the benefits of on-line coupled LC?GC using a series of applications. The pros include shorter analysis times, better reproducibility and improved detection limits.

This article illustrates the use of multiplexed microemulsion electrokinetic chromatography with UV detection to develop a rapid approach for obtaining log POW values of neutral and basic compounds.

The authors descrive the use of GC–MS to isolate and identify potentially toxic compounds in concentrated extracts of sewage treatment plant effluents.

John Hinshaw explores how to perform solid-phase microextraction and discusses the advantages provided by the technique.

The guest authors provide an overview of tissue sample preparation by discussing and comparing conventional extraction technologies an novel approaches.

The authors show how several factors can contribute to a chromatogram's appearance.

Appendix for "Separation of Toxic Coplanar PCB Congeners . . ."

This new column looks at the current importance of electrospray ionization and emerging approaches for samples that require ionization by other means, including a new technology, multimode ionization.

Dolan presents two situations in which experimental evidence is used to determine the best operating conditions.

Hinshaw provides an overview of scientific presentations and technology developments from the 26th International Symposium on Capillary Chromatography and Electrophoresis.

Majors discusses highlights from HPLC 2003, held June 2003 in Nice, France.

This column discusses the beginnings of GC in the United States and four early symposia.

Dolan responds to reader comments and questions in celebration of the 20th anniversary of "LC Troubleshooting."

John Dolan discusses the causes of peak tailing, how to measure it, preventive measures, and why newer column types are less prone to tailing problems.

This column is the first installment in a two-part series reviewing ICH and FDA impurity method validation guidelines.

This article focuses on the initial development of an LC–MS method to screen for cyanotoxins at low parts-per-billion levels.

John Hinshaw writes about the role that the American Society for Testing and Materials International plays in chromatography standardization.

The guest authors describe capillary columns for ultrahigh pressure liquid chromatography.

John Hinshaw examines developments in chromatography before 1952 that established the basis for the modern practice of GC.

The guest authors discuss current procedures for protein sample preparation, protein analysis, and automation.

This month's column addresses problems submitted by readers, including negative peaks, pressure increases, and peak-width increases.

Dolan examines the causes of LC system leaks and suggests some preventive maintenance to minimize their occurrence.

The guest authors describe sample preparation techniques based on liquid membrane extraction.

Leslie Ettre discusses the life and activities of the inventor of chromatography.

The authors test and compare performance of three types of LC–MS systems for precision, linearity, selectivity, accuracy, and sensitivity in the quantitation of drug impurities.

The authors describe GC product introductions at Pittcon 2003.

The authors discuss the advantages and disadvantages of evaporative light-scattering detection and chemiluminescent nitrogen detection for determining compounds lacking UV chromophores.