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The FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.

In this month's installment of "LC Troubleshooting," John Dolan focuses on late-eluted peaks.

Norberto Guzman and Ron Majors look at three areas in which progress has been made in improving concentration limits of detection for CE and CE microchip techniques: preconcentration methods, detector enhancements, and derivatization methods to improve separation selectivity and to enhance detection.

Leslie Ettre outlines the transition from metal tubes to glass and finally to fused-silica tubing and discusses improvements in stationary-phase technology. He also mentions some trends for further improvement of capillary column GC.

The authors compare fast LC}MS with a flow injection analysis}MS method for effective quantitation in the high-throughput environment of today's drug discovery laboratories.

John Hinshaw examines the role of autosamplers as the first link in a GC separation.

Dolan discusses some of the pitfalls that users can encounter when adjusting a gradient-elution LC method.

An introduction to SQL, the language that creates, maintains, manipulates, and queries relational databases.

Ron Majors discusses stationary-phase developments such as molecular-imprint polymers and monolithic phases. He also examines column stability, temperature as a separation variable, ultrahigh-pressure LC, and retention mechanisms.

The authors describe two tests performed using SPE. The first involved sterol isolation and cleanup of seed oils, and the second analyzed crude seed oils.

Ron Majors highlights presentation from the 24th International Symposium on High Performance Liquid Phase Separations and Related Techniques.

This column discusses the activities of a Russian pioneer of GC and outlines the principles of some of the techniques he developed.

The authors describe reversed-phase HPLC based on hybrid particles and demonstrate the packing's retention and selectivity characteristics.

Guest author S.R. Needham describes an HPLC–tandem MS method that rapidly analyzes drugs and isobaric metabolites in complex matrices.

This month's installment illustrates some potential problems that may arise during method transfer.

The authors focus on problems that may occur when converting conventional methods to LC–MS.

The author discusses the roles of MS and chromatography data systems within drug discovery analytical laboratories.

John Hinshaw examines some techniques that simulate GC results under varying conditions.

This article describes a case study in which forensic chemical analyses were conducted to determine the liability for the release of an unknown petroleum product into a river.

Guest author Barry Lesnik attempts to clarify the multiple uses of the term validation in environmental analysis.

Today's laboratories are sophisticated, generate large amounts of data and rely on electronic data collection and tracking via a laboratory information management system (LIMS).

Thermo Electron Corporation, the leading provider of analytical instruments and laboratory informatics solutions, has established a new local customer support center for its informatics software and services in Dammam, in the Eastern province of Saudi Arabia. Demonstrating its express commitment to its Middle East-based informatics customers, the new helpdesk has been developed in close collaboration with the Yusuf Bin Ahmed Kanoo group, Thermo?s partner in the region.

Applied Biosystems announced at the 2006 Annual Meeting of the American Association for Cancer Research...

Applied Biosystems announced at the 2006 Annual Meeting of the American Association for Cancer Research...

Applied Biosystems announced at the 2006 Annual Meeting of the American Association for Cancer Research...