How Liquid Chromatography is Pushing the Boundaries of Low-flow LC-MS Analysis

Liquid Chromatography Mass Spectrometry (LC-MS) is currently the most powerful tool available for quantitative and qualitative analysis of samples with a wide range of complexity. Although liquid chromatography technology plays an essential part in LC-MS analysis, it has often been overshadowed by advances in mass spectrometer performance and usability. In this series, we will uncover the crucial role of nano-, capillary-, and micro-low LC separations in proteomics and biopharma LC-MS applications.

EP. 1: Why Liquid Chromatography is a Must for Mass Spectrometry?

September 9th 2021

Alexander Boychenko, Product Marketing Manager at Thermo Fisher Scientific focused on low-flow LC technologies provides insights into the benefits of the state-of-the-art nano-, capillary- and micro-flow UHPLC system hyphenation with MS.

EP. 2: LC-MS proteomics- will micro-flow transform it into a "routine" tool?

September 27th 2021

Professor and Chair of Proteomics Bernhard Kuster from Technical University Munich in Germany is discussing how micro-flow LC changed the way of large-scale LC-MS proteomics projects execution in his laboratory.

EP. 3: Setting the Record in Deep Single-shot nanoLC-MS Proteome Profiling

October 18th 2021

In episode 3 of this six-part series, Karl Mechtler, head of the protein chemistry facility at the Research Institute of Molecular Pathology, Vienna, Austria, discusses the critical role of nano LC separation performance for reproducible and quantitative deep-dive proteomics analysis.

EP. 4: Making Ultra-Sensitive Analysis of Limited Samples and Single Cells a Reality

November 1st 2021

In the fourth episode of this six-part podcast, David Perlman, senior principal scientist and director of ultrasensitive proteomics at the Merck Exploratory Sciences Center, discusses where LC-MS proteomics has the largest impact, the need for single-cell proteomics, the promise single cells have on our day-to-day lives, and more.

EP. 5: Accelerating Productivity of NanoLC-MS Analysis with Advanced Liquid Chromatography Setups

November 17th 2021

In the fifth episode of this six-part series, Bogdan Budnik, principal scientist at Harvard Center for Mass Spectrometry, discusses common challenges related to nano LCMS proteomics analysis of very diverse sample types, improvements in proteomics analysis, and how single-cell proteomics will impact the medical field.

EP. 6: Developing Technologies for High Impact Proteomics and Protein Chemistry Research

December 1st 2021

In the final episode of this six-part podcast, Robert Moritz, a professor at the Institute for Systems Biology, discusses major challenges that still exist with liquid chromatography and mass spectrometry, liquid chromatography’s role in LC-MS proteomics, and where this field is headed in the next few years and beyond.