Thermo Fisher Scientific

The Central Dogma of Molecular Biology states the genetic information stored in our DNA is transcribed into an intermediate molecule, RNA, which is then translated into protein. There are three main types of RNA associated with transcription/translation: messenger RNA, ribosomal RNA, and transfer RNA. All RNAs in the biological system carry post transcriptional modifications: chemical functional groups added to the base, the ribose sugar, or both. The gold standard in analytical technology for identification and characterization of these modifications remains steadfast in the realm of liquid chromatography hyphenated to high resolution accurate mass spectrometry. This paper covers how the analysis of native RNA is technically demanding and how RP-based separation strategies that avoid ion-pairing reagents are in demand. It highlights the use of Orbitrap Tribid MS for system evaluation with and without sulfolane to assess retention, signal stability, and fragmentation efficiency.

Webinar Date/Time: Tue, Jan 20, 2026 11:00 AM EST

The first charged aerosol detector (CAD) was introduced in 2005. Nearly twenty years later, this near-universal detector has become an indispensable tool in the analytical chemist’s quantitative arsenal. This paper explores the CAD’s origin story, its adoption into everyday use by separation scientists, and its comparison to evaporative light scattering detector (ELSD). Technical highlights will include how parameters such as evaporation temperature influence application versatility, and how the power function impacts linearity and response behavior.

Learn how effective non-targeted analysis in soil samples is enabled through high resolution accurate mass in combination with intelligent data processing from Compound Discoverer.

This white paper highlights how the Thermo Scientific™ Orbitrap Exploris™ GC 240 mass spectrometer delivers unprecedented depth of analysis to gain deeper insights into every sample and advance your research.

Hear from Associate Professor Douglas Walker at Emory University on how GC Orbitrap MS has advanced their capability in exposomics research.

Explore the interior of the Orbitrap Exploris GC 240 to discover its key components and the experiments that can be conducted to enhance analytical flexibility.

Hear how Eurofins SOFIA GmbH successfully implemented the TSQ 9610 GC-MS/MS into their workflow for trac contaminant analysis and increased higher sample throughput using the combination of instrumentations and software.

Utilizing GC-MS/MS to quantify low levels of PBDEs in matrix samples. Including an assessment of linearity and instrument detection limits (IDLs) for all compounds as well as an extended robustness study over n=100 injections of matrix samples to assess the reproducibility of the detection of trace levels of PDBEs.

In this study, the suitability of the TSQ 9610 triple quadrupole GC-MS/MS system was assessed for the analysis of more than 200 pesticides in black tea at trace concentrations supplemented with SPE cleanup. The linearity, accuracy, precision, limit of quantitation, and injection reproducibility of 20 selected analytes representative of the different pesticide classes in black tea matrix are demonstrated.

Webinar Date/Time: Wed, Oct 16, 2024 10:00 AM EDT

The benefits of the Thermo Scientific™ Orbitrap Exploris™ GC mass spectrometer system for the analysis of trace level contaminants, such as pesticides, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and brominated flame retardants (BFRs) are showcased.

Collection of most relevant automated sample preparation workflows for the TriPlus RSH SMART autosampler, including schematics, configurations, and links to additional resources, covering environmental and food safety applications.

Webinar Date/Time: Fri, Sep 20, 2024 11:00 AM EDT

Analysis of proficiency test (PT) samples to demonstrate the benefits of combining GC-MS/MS and LC-MS/MS with the innovative Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS).

Protecting the environment with the analysis of PFAS in air

Food packaging screening using the Orbitrap Exploris GC 240 mass spectrometer and Compound Discoverer software enable sensitive compound detection and identification.

In this poster find out how hydrogen can be used safely as GC carrier gas for pesticides analysis at trace levels.

Detecting and identifying untargeted environmental contaminants in a complex matrix

Analyzing PAHs in accordance with U.S. EPA 8270E utilizing Hydrogen as a carrier gas.

Using a single GC-MS/MS configuration to monitor environmental contaminants including pesticides, micropollutants and POPS.

Ensuring safe drinking water utilizing GCMS couple with purge and trap

Hear how Eurofins GfA Lab Service utilize Orbitrap Exploris GC for food analysis

The utility of the Thermo Scientific™ TRACE™ 1610 GC system and the Thermo Scientific™ TSQ™ 9610 triple quadrupole GC-MS/MS for the analysis of ethylene oxide and 2-chloroethanol residues in food

Raman spectroscopy is the ideal approach to compositional analysis and provides great versatility. In this Q&A, Tom Dearing, Senior Staff Scientist, and John Richmond, Senior Sales Manager, both at Thermo Fisher Scientific, provide an overview of the MarqMetrix All-In-One Process Raman Analyzer.

identification and quantification of 34 target PFAS at parts-per-trillion levels in pork, plus retrospective analysis of sample data files for other untargeted PFAS.

High-quality data is critical in the pharmaceutical industry. Chromatography Data Systems (CDS) are helping organizations ensure data integrity, compliance with regulatory requirements, and the production of safer medicines.

Webinar Date/Time: Mon, Nov 13, 2023 10:00 AM EST

Identifying and Mitigating Contamination Ions in Mass Spectrometry: A Comprehensive Guide