LCGC Advances In Gas Chromatography 11.23-11.24

Thermo Fisher Scientific

Articles by Thermo Fisher Scientific

Sponsored Content

See how combustion ion chromatography can be used to determine total organic fluorine in textiles as manufacturers respond to evolving PFAS requirements. This application proof note demonstrates a C-IC workflow using the Cindion Combustion Ion Chromatography System and Dionex Inuvion IC system.

Sponsored Content

PFAS testing requirements vary by matrix and analytical goal. See workflows spanning sample preparation, targeted LC-MS/MS analysis, combustion ion chromatography, high-resolution mass spectrometry and data processing for water, soil and other challenging samples. The guide also compares approaches for known PFAS quantitation and unknown screening.

Sponsored Content

See how Professor Lee Ferguson's laboratory at Duke University combines high-resolution mass spectrometry, Compound Discoverer software and advanced cheminformatics to investigate complex PFAS mixtures. The work includes a spectral library of more than 46,000 known and predicted compounds to support identification of known, unexpected and emerging PFAS.

Sponsored Content

Get an overview of PFAS sources, environmental pathways and analytical approaches across industrial and environmental applications. This roadmap connects routine targeted testing with broader investigational workflows, including sample preparation, LC-MS/MS, combustion ion chromatography and high-resolution mass spectrometry.

Sponsored Content

Explore a semi-automated approach to PFAS analysis in soil designed to meet US EPA Method 1633A performance requirements. The workflow automates extraction and sample clean-up to increase throughput, reduce manual handling and help minimize opportunities for error and PFAS contamination.

Sponsored Content

Explore the use of adsorbable organic fluorine and combustion ion chromatography to screen for PFAS in wastewater. This application note presents results from the EPA Method 1621 multi-laboratory collaboration study, including practical guidance for adsorption, combustion, ion chromatography and method implementation.

Routine, high-throughput laboratories must balance analytical speed, sensitivity, uptime, and reproducibility while managing demanding quantitative workflows. This Instrument Insights explores how the Thermo Scientific™ TSQ Certis Triple Quadrupole Mass Spectrometer (MS) is designed to address these challenges. Ready-to-run workflows and compliance-ready software support can simplify method development and routine operation across clinical research, toxicology, food safety, environmental, and biopharma applications. In addition, performance data demonstrates the robustness in complex matrices and long analytical sequences.

Sponsored Content

The Central Dogma of Molecular Biology states the genetic information stored in our DNA is transcribed into an intermediate molecule, RNA, which is then translated into protein. There are three main types of RNA associated with transcription/translation: messenger RNA, ribosomal RNA, and transfer RNA. All RNAs in the biological system carry post transcriptional modifications: chemical functional groups added to the base, the ribose sugar, or both. The gold standard in analytical technology for identification and characterization of these modifications remains steadfast in the realm of liquid chromatography hyphenated to high resolution accurate mass spectrometry. This paper covers how the analysis of native RNA is technically demanding and how RP-based separation strategies that avoid ion-pairing reagents are in demand. It highlights the use of Orbitrap Tribid MS for system evaluation with and without sulfolane to assess retention, signal stability, and fragmentation efficiency.

Sponsored Content

The first charged aerosol detector (CAD) was introduced in 2005. Nearly twenty years later, this near-universal detector has become an indispensable tool in the analytical chemist’s quantitative arsenal. This paper explores the CAD’s origin story, its adoption into everyday use by separation scientists, and its comparison to evaporative light scattering detector (ELSD). Technical highlights will include how parameters such as evaporation temperature influence application versatility, and how the power function impacts linearity and response behavior.

Sponsored Content

In this study, the suitability of the TSQ 9610 triple quadrupole GC-MS/MS system was assessed for the analysis of more than 200 pesticides in black tea at trace concentrations supplemented with SPE cleanup. The linearity, accuracy, precision, limit of quantitation, and injection reproducibility of 20 selected analytes representative of the different pesticide classes in black tea matrix are demonstrated.