A Comparison of CE–MS and LC–MS for Peptide Samples

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A Comparison of CE–MS and LC–MS for Peptide Samples

January 1, 2000

Maria Serwe, Gordon A. Ross

LCGC North America, January 2000, Volume 18, Issue 1

Pages: 46–55

The authors investigated and compared aspects of capillary electrophoresis and liquid chromatography coupled with electrospray-ionization mass spectrometry for the analysis of peptide samples. Despite their different levels of technological maturity, both techniques can be operated at the same level of automation. However, they differ greatly in the interface design, selectivity, sensitivity, and method development aspects.