Accurate and sensitive all-ions quantification using ultra-high resolution LC-MS
Endogenous metabolite profiling is an extreme example of multi-component quantitative analysis. Triple quadrupole mass spectrometers are considered the gold standard for quantification using selected reaction monitoring (SRM). However, as the number of analytes increases, SRM method development becomes more labour intensive. Using shorter SRM dwell times to accommodate more components compromises sensitivity and precision. In contrast, ultra-high resolution LC–MS provides a highly sensitive and relatively unbiased quantitative assessment of metabolomics samples, without the need for MS–MS; it also obviates the need for multiple platforms for profiling and validation.
Carol Robinson Awarded 2024 Lifetime Achievement European Inventor Award
July 24th 2024Carol Robinson of the University of Oxford has received the European Inventor Award 2024 for Lifetime Achievement from the European Patent Office for her work bringing mass spectrometry to structural biology.
Microseparations and Analysis Covered at HPLC 2024
July 23rd 2024At HPLC 2024 in Denver, Colorado, various sessions will be led by experienced scientists, covering different aspects of chromatography techniques and maximizing their effectiveness. Here is some information about tomorrow’s sessions.
Automated LC Method Development: An HTC-18 Interview with Bob Pirok
July 23rd 2024At HTC-18 in Leuven, Executive Editor of LCGC International, Alasdair Matheson, spoke to this year’s winner of the 2024 HTC-18 Innovation Award, Bob Pirok from the University of Amsterdam, about his innovative research on automated LC method development.