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|Articles|September 1, 2008
- The Application Notebook-09-01-2008
- Volume 0
- Issue 0
Analysis of Voglibose in Pharmaceutical Formulations by HPLC with Post-Column Derivatization
Voglibose is an Alpha-Glucosidase inhibitor widely used for the treatment of diabetes. Alpha-glucosidase inhibitors are agents that delay the glucose absorption at the intestinal level and thereby prevent sudden surge of glucose after a meal. Voglibose is the safest and most effective drug of its class.
Maria Ofitserova Ph.D., Sareeta Nerkar, Ph. D., and Michael Pickering Ph.D., Pickering Laboratories
Voglibose is an Alpha-Glucosidase inhibitor widely used for the treatment of diabetes. Alpha-glucosidase inhibitors are agents that delay the glucose absorption at the intestinal level and thereby prevent sudden surge of glucose after a meal. Voglibose is the safest and most effective drug of its class.
Table I: Repeatability studies for different concentration levels
Since Voglibose has no UV chromophore, post-column deriv-atization is employed to produce a fluorescent derivative.
Figure 1
This abstract describes a very sensitive and robust analytical method for the analysis of Voglibose in pharmaceutical tablets. Simple sample preparation and fast analysis time allow for using this method in high throughput environments.
Figure 2
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