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|Articles|April 1, 2004

LCGC Europe

  • LCGC Europe-04-01-2004
  • Volume 17
  • Issue 4

Anatomy of a Peak

This month's column examines the basic measurements of a peak's size and shape for the purposes of assessing and monitoring chromatographic separations over a period of time.
External Link - article-92337.pdf

Articles in this issue

over 22 years ago

Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery Applications

over 22 years ago

New Chromatography Columns and Accessories at the 2004 Pittcon Conference, Part I

over 22 years ago

Success with Evaporative Light-Scattering Detection, Part II: Tips and Techniques

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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting Column Insertion Distance
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
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