Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery Applications

Here is some of the most popular content posted on LCGC International this week.

Aqueous two-phase systems have become more popular as biomanufacturers look to adopt continuous processing. However, there are several uncertainties regarding widespread use of this technique.

LCGC International spoke to Craig Wheelock and Matthew Smith from the Wheelock Laboratory at the Karolinska Institute, Sweden, about a novel desorption electrospray ionization–multiple-reaction-monitoring mass spectrometry (DESI-MRM-MS) workflow his team has developed to spatially map oxylipins in pulmonary tissue.

This article explores the integration of high-resolution ion mobility spectrometry–mass spectrometry (HRIMS-MS) with liquid chromatography (LC) and quadrupole time-of-flight mass spectrometry (QTOF-MS) as a comprehensive workflow for PFAS analysis.