Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery Applications

April 1, 2004
Pat Sandra

,
Gregory Woo

,
Yining Zhao

,
Samuel Thomas

,
Kyung Gahm

,
David Semin

LCGC Europe

LCGC Europe, LCGC Europe-04-01-2004, Volume 17, Issue 4
Page Number: 224–238

This article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.

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