|Articles|April 1, 2004

LCGC Europe

  • LCGC Europe-04-01-2004
  • Volume 17
  • Issue 4

Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery Applications

This article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.


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A three-year study of medical students and doctors in training tracked burnout symptoms alongside inflammation markers and morning cortisol and cortisone levels in saliva, measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS), to better understand the biology of burnout.