Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery Applications

April 1, 2004
Pat Sandra

Gregory Woo

Yining Zhao

Samuel Thomas

Kyung Gahm

David Semin

LCGC Europe

LCGC Europe, LCGC Europe-04-01-2004, Volume 17, Issue 4
Pages: 224–238

This article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.