This February 2011 edition of The Application Notebook is the 10th Anniversary of publishing these supplements and further affirms the valuable service they perform in the chromatography community.
This February 2011 edition of The Application Notebook is the 10th Anniversary of publishing these supplements and further affirms the valuable service they perform in the chromatography community. The enthusiastic support of readers and advertisers has been ample reward for the hard work and dedication to excellence that the LCGC staff puts into these publications.
While LCGC North America performs an important service each month, we continue to hear about the need for more applications-oriented information from readers and advertisers across virtually every discipline served by the separation sciences. And while the material contained herein has not been rigorously peer-reviewed — as are the articles that appear in LCGC — we continue to provide the latest methodological developments to scientists not only in the print application notebook format but in various online vehicles: digital editions, application note alerts, and e-newsletters.
Application notes continue to be a great opportunity for suppliers of chromatography instruments, columns, and accessories to inform the scientific marketplace about the latest applications and areas of method development for their products. Feel free to contact me, Ed Fantuzzi, or Stephanie Shaffer about additional advertising and marketing opportunities for both print and online products.
In addition, LCGC is proud to be producing live vidcasts from out Pittcon Theater, set to run Monday, March 14 through Wednesday, March 16, at booth #3217 in the Georgia World Congress Center. The first two days of the theater will see a lineup of the industry's most respected and well-known experts speaking on topics from HPLC/UHPLC to GC, GC–MS, and LC–MS, bringing listeners cutting-edge information in the field of separation science. The third day will be dedicated to LCGC's online social networking and training site, CHROMacademy, and will also feature speakers and applications from all areas of chromatography.
Enjoy the issue. We look forward to seeing you in Atlanta.
Michael J. Tessalone Michael J. Tessalone
Science Group Publisher
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
RP-HPLC to Compare Genotoxic Impurities in Extracted and Synthetic Nicotine
November 7th 2024A recent study examined the impurity profile of thirteen different lots of synthetic nicotine and compared them to fourteen lots of nicotine extracted from plants using in-house analytical methods, with samples tested for alkaloids and phenols with reversed-phase high-performance liquid chromatography (RP-HPLC).