Technology Spotlight: Back To The Future - Slalom Chromatography Revisited

LCGC International spoke to Fabrice Gritti, consultant scientist at Waters Corporation, about the history of slalom chromatography (SC) and why he decided that the technique was worth re-investigating. Gritti describes the advances in separation science technology that have made slalom chromatography a viable modern technique to investigate DNA and RNA molecules. The potential benefits of SC, according to Gritti, include identifying RNA impurities when manufacturing mRNA therapeutics, and assisting in the development of new gene and cell therapies, and other biopharmaceutical applications.

Fabrice G. Gritti received a PhD in chemistry and physics of condensed matter from the University of Bordeaux I (France) in 2001. He worked as a research scientist at the University of Tennessee (Knoxville, Tennessee, USA) from 2002–2014 in the research group of the late Professor Georges Guiochon. He joined Waters Corporation in 2015 where he is currently a consulting scientist.

Alasdair Matheson is currently the executive editor for LCGC International and was previously editor-in-chief of LCGC Europe. He has a master’s degree in analytical chemistry from Strathclyde University (Scotland), specializing in chromatography, and a postgraduate diploma in marine pollution chemistry from Liverpool University.