Best of the Week: Plasma Biomarkers, Forensic Analysis, Productivity in the Lab

This week, LCGC International published a variety of articles on hot topics in separation science. From a feature article on how to improve productivity in the laboratory to spotlighting some of the latest research in forensic analysis, we remain dedicated to sharing the latest in chromatographic advancements. Below, we’ve highlighted some of the most popular articles that were published this week.

Uncovering Plasma Biomarkers for α-Synucleinopathies Using Targeted Mass Spectrometry

α-synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, involve the buildup of misfolded α-synuclein in the brain, making early diagnosis difficult because of overlapping symptoms. Although cerebrospinal fluid assays show promise, plasma α-synuclein has been less useful because of its high expression outside the brain (1). Recent research suggests that disease-specific truncations and phosphorylation patterns may serve as more accurate biomarkers. Pablo Mohaupt, Marie-Laure Pons, and colleagues at Montpellier’s Clinical Proteomics Platform and Shimadzu Corporation developed an mass spectrometry (MS)-based method to measure α-synuclein peptides in plasma, aiming to detect biochemical signatures for earlier, more precise diagnosis (1). In this interview, Mohaupt discusses his team’s work.

“Flip-Flopping” Forensic Analysis

Ira Lurie is a professional lecturer at George Washington University who has been conducting work in forensic drug analysis. In this interview, Lurie discusses his work developing innovative chromatographic methods to enhance forensic drug analysis. He describes “flip-flop” chromatography, which uses silica hydride stationary phases to seamlessly switch between reversed-phase and aqueous normal-phase separations without changing solvents, improving analytical efficiency (2). Lurie also highlights derivative gas chromatography–vacuum ultraviolet spectroscopy (GC–VUV) as a powerful tool for distinguishing difficult synthetic cannabinoid isomers (2). This capability is crucial in forensic science, where precise isomer identification can have significant legal and investigative implications (2). His research advances both the specificity and speed of analytical techniques in forensic casework.

Unpacking the Analytical Toolbox for PFAS: From Targeted Quantitation to Unknowns

A recent article on per- and polyfluoroalkyl substances (PFAS) highlights the analytical challenges of these "forever chemicals." A panel of leading scientists, including Rainer Lohmann, Natalia Soares Quinete, Stefan van Leeuwen, and Carrie McDonough, discussed the need for robust detection methods (3). Mass spectrometry (MS) is the core of PFAS analysis, with targeted methods used for known compounds and high-resolution mass spectrometry (HRMS) for discovering new ones (3). The article also covers challenges in the analytical workflow, such as sample preparation, matrix effects, a lack of commercial standards, and evolving regulations (3). Ultimately, a combination of analytical techniques and interdisciplinary collaboration is needed to address the complex issue of PFAS.

Rethinking Productivity in the Lab

A recent study published in PNAS examined that over 12,000 U.S. tenure-line faculty found that publication rates peak just before tenure, with laboratory fields maintaining higher post-tenure output than non-lab disciplines (4). Once tenure is achieved, researchers often gravitate toward riskier, more novel research, though pressure to produce remains intense in both academia and industry. The “slow work” movement challenges this high-speed culture, advocating for longer timelines, deeper reflection, and collaborative spaces to foster creativity and sustain innovation (4). Experts argue that prioritizing quality over quantity not only enhances research impact but also protects mental health, builds stronger teams, and supports long-term scientific progress (4).

Rapid Detection of Ethyl Carbamate in Chinese Liquor

A study published in Talanta by researchers at the Dalian Institute of Chemical Physics introduced a rapid, high-throughput method for detecting the carcinogen ethyl carbamate (EC) in alcoholic beverages (5). The technique, combining gas chromatography with photoionization-induced chemical ionization time-of-flight mass spectrometry (FastGC-PICI-TOFMS), delivers accurate results in under four minutes without sample pre-treatment. It achieves a low detection limit of 4.4 µg L⁻¹, strong reproducibility, and versatility across different liquors (5). By enabling faster, cost-effective screening, the method supports regulatory compliance, enhances quality control, and could be adapted for broader use in monitoring EC in wines, spirits, and other fermented products.

References

1. Chasse, J. Uncovering Plasma Biomarkers for α-Synucleinopathies Using Targeted Mass Spectrometry. LCGC International. Available at: https://www.chromatographyonline.com/view/uncovering-plasma-biomarkers-for--synucleinopathies-using-targeted-mass-spectrometry (accessed 2025-08-14).
2. Jones, K. “Flip-Flopping” Forensic Analysis. LCGC International. Available at: https://www.chromatographyonline.com/view/-flip-flopping-forensic-analysis (accessed 2025-08-14).
3. Hroncich, C. Unpacking the Analytical Toolbox for PFAS: From Targeted Quantitation to Unknowns. LCGC International. Available at: https://www.chromatographyonline.com/view/unpacking-the-analytical-toolbox-for-pfas-from-targeted-quantitation-to-unknowns (accessed 2025-08-14).
4. Hroncich, C. Rethinking Productivity in the Lab. LCGC International. Available at: https://www.chromatographyonline.com/view/rethinking-productivity-in-the-lab (accessed 2025-08-13).
5. Wetzel, W. Rapid Detection of Ethyl Carbamate in Chinese Liquor. LCGC International. Available at: https://www.chromatographyonline.com/view/rapid-detection-of-ethyl-carbamate-in-chinese-liquor (accessed 2025-08-14)