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News|Articles|August 17, 2026

Characterizing Conjugated Therapeutics: Advanced LC-MS Strategies for PQAs, Aggregates and Conjugation Sites

Author(s)SCIEX

Comprehensive characterization of biotherapeutics requires advanced analytical strategies capable of detecting and identifying low-abundant product quality attributes (PQAs), including post-translational modifications, aggregates, sequence variants, and conjugation sites. This eBook presents three technical articles demonstrating advanced LC-MS workflows that achieve up to 10X improvement in MS sensitivity for trace-level detection and confident identification of these challenging attributes.


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