Chromatographic Characterization of Biologics
Characterizing biologics through chromatographic analysis.
Protein biologics now represent a significant share of pharmaceutical sales and future growth potential, particularly in an era of increasing patent expirations and generic versions of small-molecule drugs. Their specificity has been their key to success, as their cell-specific modality and relative lack of compound-specific toxicity have provided safer and more effective means to treat several chronic diseases. Sufferers of rheumatoid arthritis and other autoimmune diseases, cancer and diabetes have been among the benefactors of the protein biologics developed to date. The most common class of proteins used as pharmaceuticals has been monoclonal antibodies (mAbs), representing over 30% of the global biologic drug market, according to a recent market report, and there are more than 20 FDA approved mAb drugs already on the market.
Nanospray Laser-Induced Plasma Ionization Mass Spectrometry to Analyze Persistent Organic Pollutants
September 3rd 2024Scientists from the Guangdong Academy of Sciences and the Guangdong University of Technology used nanospray laser-induced plasma ionization mass spectrometry (nLIPI-MS) to analyze broad polarity organic pollutants under ambient and open-air conditions.
Dispersive Solid Phase Microextraction for Detecting PAHs in Juice and Water
August 29th 2024Dokuz Eylul University scientists tested dispersive micro solid-phase extraction (D-µSPE)’s effectiveness for detecting polycyclic aromatic hydrocarbons (PAHs) in fruit juice and environmental water samples.
