News|Articles|January 21, 2026

Efficient Method Development Based on Analytical Quality by Design

This article describes the efficient development of robust analytical methods based on Analytical Quality by Design (AQbD) using dedicated LabSolutions MD software, which supports each phase of the process – screening, optimization, and validation – using functions such as experimental design, building of design space by automatic Peak Tracking, and robustness evaluation.


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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
Basel, Switzerland. Old town with red stone Munster cathedral on the Rhine river. © SCStock - stock.adobe.com
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