Shimadzu Corporation | Authors


Achieving Improved Sensitivity and Reliable Analytical Performances in Nucleotides Analysis

This app note introduces the use of the Nexera XS inert UHPLC, which utilizes a metal-free flow path for accurate and reproducible analysis of nucleotides.  

Method Optimization for the Analysis of Monoclonal Antibodies by Size-Exclusion Chromatography

This technical report covers how a column packed with small particle material can be used to optimize an analytical method for monoclonal antibody aggregates. 

Oligonucleotides Analysis by Ion-Exchange Chromatography and Effect of pH Changes in the Mobile Phase on Separation

This app note introduces an analytical method for the separation of oligonucleotides of different length by ion-exchange chromatography using the Nexera XS Inert. 

Analysis of Protein Drugs Aggregation Using Size-Exclusion Chromatography

This app note covers aggregate analysis using a Shimadzu Shim-pack™ BioDiol size-exclusion chromatography column with the Nexera XS inert UHPLC.  

Automated Analysis of 37 D/L-Amino Acids Using LC with Fluorescence Detection

This application introduces the automated analysis of fluorescent diastereomers of the proteinogenic D/L-amino acids using derivatizing reagents with chiral structures.