Evaporative light scattering (ELS) is a unique and highly sensitive technique for detection of semivolatile and nonvolatile solutes in a liquid stream. As a consequence of the physics of light scattering, conventional ELS detectors have a relatively small dynamic range. In contrast, the Agilent 1290 Infinity II Evaporative Light Scattering Detector has a 10-times higher dynamic range compared to conventional ELS detectors.
Analyze Charge Variants in Antibody-Based Therapeutics Using Cation Exchange Chromatography
July 18th 2024This application note discusses the latest development on high performance cation exchange bio-separation columns for determining charge variants in protein-based biotherapeutics, as well as the strategy on method development.