LCGC UST
|Articles|March 1, 2005

LCGC Europe

  • LCGC Europe-03-01-2005
  • Volume 18
  • Issue 3

Flow, Pressure and Temperature Calibration: Part 2

In the concluding part of this series, the effects that column variability has on isothermal capillary gas chromatography is discussed and instrument calibration explored. The goal is to reduce the normal variability that occurs when working with multiple instruments and columns to ensure consistent results.


Related to this article

Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.