Guide to LC Troubleshooting 2025

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) finds low glyphosate residues of the weedkiller glyphosate in coffee beans.

This week, Chromatography Online explored how the technique is advancing wastewater drug monitoring, siRNA method development, and food safety testing, with previews of RAFA 2026 and a return to HPLC fundamentals with Michael Dong.

Recent EU legislation on PFAS shifts from monitoring individual compounds toward managing them as a chemical class.

In this seventh part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why 2.1-mm i.d. columns are less preferred for pharmaceutical quality control.

Ultrahigh-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) shows how soaking and cooking break down soybean fats.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) links altered metabolism to lingering symptoms in Ebola survivors.

Nicolai Zederkopff explores chromatography’s role to help implement the maximum tolerable level (MTL) framework for food adulteration to translate analytical results into compliance decisions.

Franz Berthiller (BOKU University, Austria) discusses a multilaboratory study that used retention index markers to align mycotoxin liquid chromatography–mass spectrometry (LC–MS) data.