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Bruker Daltonics announces ETD II, a next-generation ETD (electron transfer dissociation) module for its HCTultra™ high capacity ion traps.
Bruker Daltonics announces ETD II, a next-generation ETD (electron transfer dissociation) module for its HCTultra high capacity ion traps. ETD is a very powerful peptide and protein fragmentation technique that preserves functionally important post-translational modifications (PTMs), such as phosphorylations or glycosylations. With ETD in a spherical high-capacity ion trap, the sequencing and identification of proteins, as well as the identification and localization of PTMs are facilitated with greatly improved scores and confidence.
In 2005, Bruker Daltonics introduced the first commercial ion trap equipped with ETD, which quickly became the market leader for ETD-ITMS. In 2007, the related PTR (Proton Transfer Reaction) technology was first introduced commercially by Bruker. With proven market and performance leadership in ETD/PTR, Bruker now enhances this key proteomics technology even further with the introduction of the improved ETD II accessory. ETD II is based on a novel and compact nCI (negative chemical ionization) source with increased ETD/PTR reactant ion generation, resulting in rapid, sub-fmol sensitivity for the confident characterization of PTMs.