 Can you briefly explain the theory of HILIC chromatography?

 Hydrophilic interaction liquid chromatography or HILIC is a technique that has really been around for quite some time, based somewhere between reversed-phase (RP) and normal-phase (NP) chromatography. A highly polar stationary phase, often bare silica, is used with largely a non-polar mobile phase system (water acting as a very strong solvent in HILIC) to provide retention of polar or hydrophilic molecules.

HILIC

E-Separation Solutions-02-03-2011

LCGC's The Column editor, Janet Kelsey, spoke to Mark Woodruff of Fortis Technologies about the background, advantages, and applications of hydrophilic interaction chromatography and where its future lies.