Today at 4:45 pm, John B. Fenn Distinguished Contribution in Mass Spectrometry Award recipient Evan R. Williams will give a plenary lecture. Williams is a Distinguished Professor of Chemistry and Biophysics at the University of California, Berkeley.
Williams has made pioneering contributions that have improved the fundamental understanding of ion chemistry in aqueous nanodrops both inside and outside the mass spectrometer. His work has had tremendous impact and represents a cohesive and successful sustained effort to understand the chemistry occurring in aqueous solutions during the transition in the electrospray process from bulk solution to individual ions or solvated ions.
He has taken advantage of nanodrop chemistry to: 1) manipulate ion charging and desalting ions during the electrospray ionization process, 2) develop rapid mixing in electrospray droplets to investigate ultrafast chemistry (<1 to 100 microseconds) to track peptides and fast-folding proteins in the act of folding, 3) investigate how the organization of water around ions can pattern the hydrogen bonding network of water and how water can affect the structure of ions, and 4) develop thermochemical methods, including blackbody infrared (IR) radiative dissociation and ion nanocalorimetry, to probe the thermochemistry of processes, such as electrochemical reductions in mass selected aqueous nanodrops.
This collective theme has influenced not just the field of MS and ion chemistry but has also improved our understanding about the role of water on ion chemistry in a given solution, an outcome that impacts many areas ranging from biomolecule structure and folding to atmospheric aerosol chemistry.
Inside the Laboratory: The Gionfriddo Group at the University at Buffalo
March 28th 2024In this edition of “Inside the Laboratory,” Emanuela Gionfriddo, PhD, an associate professor of chemistry at the University at Buffalo, discusses her group’s current research endeavors, including using solid-phase microextraction (SPME) coupled to liquid chromatography (LC) and gas chromatography (GC) to further understand the chemical relationship between environmental exposure and disease and elucidate micropollutants fate in the environment and biological systems.
Transferring Methods to Compact and Portable HPLC
February 14th 2024The current trend in laboratory equipment design is the miniaturization of laboratory instruments. Smaller-scale HPLC instruments offer benefits that cannot be matched by analytical-scale equipment, especially in the areas of portability, reduced fluid volumes, and reduced operating costs. Yet, the miniaturization of laboratory equipment has brought with it a unique set of challenges, including transferring methods to compact LC. Capillary LC expands the use of LC to applications not currently done using conventional LC in a wide array of application areas, including pharmaceutical, food and beverage, petrochemical, environmental, and oil and gas. Greg Ward, Axcend’s CEO wrote, “Customers want an HPLC system with a small footprint, low flow rates and green chemistry.” Join his podcast where he shares method transfer in these application areas.