Method Development and Impurity Control in Late-Phase API Manufacturing

Koji Yamaguchi of the International University of Health and Welfare (Narita, Japan) discusses a novel derivatized liquid chromatography-tandem mass spectrometry (LC-MS/MS) method plus propofol glucuronide (PRG) marker which improves forensic propofol detection.

Gas chromatography-mass spectrometry (GC-MS) coupled with headspace solid-phase microextraction )HS-SPME) links cocoa variety to chocolate aroma and flavor profiles.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identifies blood metabolite patterns tied to children's diets.

Kirstine Nielsen of Aarhus University (Denmark) discusses how targeted metabolomics ratios helped build a robust bloodstain time-since-deposition tool.

This new liquid chromatography-tandem mass spectrometry- quadrupole ion trap (LC-MS/MS-QTRAP) method identifies rat poisons in cat forensic cases.

Gérard Hopfgartner explains how atmospheric pressure photoionization can generate radical cations in LC–MS, unlocking EI-style spectra and NIST's spectral library.

Isabelle Kohler traces her unplanned path from pharmacy to bioanalysis, and why the same career struggles cut across gender lines in her PhD coaching.

LCGC International spoke to Akina Nara of Japan’s Tohoku Medical and Pharmaceutical University about a new study which links a blood compound to how long a body has been dead.