N-Rich Technology: A Novel Approach for Isolating Difficult-to-Purify Compounds

Are you struggling to purify low-abundance compounds from complex mixtures? Discover a twin-column continuous chromatography process that dramatically boosts productivity and purity, solving a critical bottleneck.

Register Free: https://www.chromatographyonline.com/ca_w/novel-approach

Event Overview:

The purification of process-related impurities is a critical, yet often challenging, step in biopharmaceutical development. Traditional batch chromatography forces a difficult trade-off between purity and productivity, making obtaining the milligram quantities of high-purity side-compounds needed for structural and safety studies slow and costly. This webinar will introduce the N-Rich process, a novel twin-column continuous chromatography method that overcomes these limitations. Using case studies on peptides, oligonucleotides, and mAb purification, this presentation will demonstrate how this automated technology can increase productivity by over 10-fold while simultaneously achieving purities of ~90% for previously difficult-to-isolate compounds.

Key Learning Objectives:

• Understand the principles of the N-Rich twin-column continuous process.
• Learn how to increase compound isolation productivity by over 10x vs. HPLC.
• See how to achieve up to 90% purity for low-abundance peptide, oligonucleotide, and mAb impurities.

Who Should Attend:

• Liquid Chromatography Specialists
• Downstream Process Development Scientists
• Purification Scientists
• Analytical Scientists
• CMC Leads
• Lab Managers in Pharma/Biotech
  

Speakers:

Thomas Müller-Späth
CEO
YMC ChromaCon

Thomas Müller-Späth, PhD, is the CEO and cofounder of ChromaCon AG. He holds a chemical engineering degree from TU Hamburg and UC Berkeley and earned his PhD at ETH Zurich, focusing on continuous chromatography. A leading expert in the field, Müller-Späth is the inventor of several patents and has authored numerous scientific articles on continuous chromatography for biopharmaceuticals, shaping modern purification processes.

J Preston, PhD
Separation Sciences Director
YMC America

J Preston, PhD, Director of Separation Sciences at YMC America, has years of experience focused on chromatography in the pharmaceutical industry, and has worked for multiple pharmaceutical companies. With a Doctorate in Analytical Chemistry from the University of Illinois, he has published numerous peer-reviewed articles and has given many presentations at national and international meetings.

Register Free: https://www.chromatographyonline.com/ca_w/novel-approach