Native online SCX-MS of monoclonal antibodies

This application note demonstrates a novel composite technology that enhances reproducibility of solid phase extraction compared to a traditional loose packed format.

In this short note, we will consider the selection of LC procedures to isolate ezetimibe from several of its degradants and show how data automation improves the process.

ZipChip-MS streamlines mAb charge variant characterization, eliminating the need for method development. Data is seamlessly processed in Byos. This note outlines an expeditious workflow for biosimilarity assessment among mAbs.

In this study, we present an ion-pairing-free method for AXPs analysis using microchip CE-MS. This fast, simple method achieves baseline resolution for Adenosine, AMP, ADP, and ATP. Excellent linearity and sensitivity are observed in human plasma.