Profiles in Practice Series: Metabolism Identification and Structural Characterization in Drug Discovery

Article

LCGC Europe

LCGC EuropeLCGC Europe-06-01-2005
Volume 18
Issue 6
Pages: 330–336

In this initial instalment, several MS technologies and strategies currently being applied to characterize drug candidates in early stage development are presented.

External Link - article-162390.pdf

Articles in this issue
HPLC Analysis of Non-volatile Analytes Using Charged Aerosol Detection
Separating Proteins by pI-Values — Can 2D LC Replace 2D GE?
Profiles in Practice Series: Metabolism Identification and Structural Characterization in Drug Discovery
Adjusting Conditions for a Routine Reversed-Phase HPLC Assay, Part 2: Changing Separation Conditions
Overload or Minor Peak
Determining the Hydrocarbon Oil Index in Water using Ultra Fast Gas Chromatography
Recent Videos
Christopher Pohl and Katelynn A. Perrault | Image Credit: © Ricky Haldis
Boston, Massachusetts, USA Downtown Skyline | Image Credit: © SeanPavonePhoto - stock.adobe.com.
Related Content
Two glass of water and colorful stripes paper. White background. Equipment prepared for doing science experiment about chromatography. Easy activity chemistry lesson for kid. | Image Credit: © Sanhanat - stock.adobe.com

Development of Hydrophobic Deep Eutectic Solvents’ Reviewed in New Paper

Aaron Acevedo
March 20th 2025
Article

Hydrophobic deep eutectic solvents have proven useful in extracting non-polar target compounds, though researchers have shown there is room for further development.

Ep. 34: A Banner Year for Separation Science at Pittcon 2025

Ep. 34: A Banner Year for Separation Science at Pittcon 2025

March 14th 2025
Podcast
Image courtesy of author

Beyond the PhD: Charting Your Path to Career Success

Isabelle Kohler
March 20th 2025
Article

What’s the next step in your career?

Ep. 33: Automating Multivariate Calibrations: Chronicling the Steps for Replacing the Human Brain in Most Calibration Situations

Ep. 33: Automating Multivariate Calibrations: Chronicling the Steps for Replacing the Human Brain in Most Calibration Situations

February 10th 2025
Podcast
Neural network 3D illustration. Big data and cybersecurity. Data stream. Global database and artificial intelligence. Bright, colorful background with bokeh effect: © Siarhei - stock.adobe.com

Improving Suspect Compound Identification in Comprehensive Two-Dimensional Liquid Chromatography High-Resolution Mass Spectrometry Data Workflows

Kate Jones
March 20th 2025
Article

A two-step workflow to extract pure mass spectra from comprehensive two-dimensional liquid chromatography high-resolution mass spectrometry (LC×LC–HRMS) data has been created and tested.

医療イメージ　医薬品 | Image Credit: © cassis - stock.adobe.com

Determining N-Nitrosamines in Pharmaceutical Preparations Using LC–MS/MS

Aaron Acevedo
March 20th 2025
Article

A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.