Researchers at the Chinese Academy of Sciences and Tsingua University have developed an automated on-line HPLC-MS method allowing injection of a large volume of urine for the improvement of sensitivity using estrogens as analytes.
Researchers at the Chinese Academy of Sciences and Tsingua University have developed an automated on-line HPLC-MS method allowing injection of a large volume of urine for the improvement of sensitivity using estrogens as analytes. The injection volume, reporetedly, increased ten times compared with conventional on-line LC-MS methods for biofluid analysis. Moreover, no obvious increase of column pressure was observed after 300 injections. The method was validated by spiking urine. Linearity was determined by sample which was in the range of 1-500 ng/mL. The process efficiency ranged from 70.2 to 106% with RSDs less than 15% with the exception of a few analytes.
Best of the Week: What’s New in MS, 2024 Young Chemist Award Winner
March 22nd 2024This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!
Inside the Laboratory: The Schug Group at the University of Texas at Arlington
March 22nd 2024In this edition of “Inside the Laboratory,” Kevin Schug, PhD, a full professor of chemistry at the University of Texas at Arlington, discusses his laboratory’s group work in environmental monitoring around water and soil quality near oil and gas extraction, using techniques such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and coupling these techniques with mass spectrometry (MS).