Scientific Town Hall Meeting: Biophysical Tools for Vaccine Characterization and Virus Research

May 28, 2020

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Join us for a Scientific Town Hall Meeting on biophysical tools for vaccine research and development. Live: Thursday, May 28, 2020 at 8am CST | 9am JST| 10am AEST On demand available after airing until May 28, 2021 Register free

Register free: http://www.chromatographyonline.com/lcgc_w/biophysical_tools

Event Overview:
In response to the global focus on vaccines and therapies for COVID-19, we invite you to a Scientific Town Hall meeting on biophysical characterization of vaccines and viruses. In this virtual event, Wyatt’s light scattering experts will provide a concise overview of how the light scattering toolkit is applied in these fields, then open the floor to audience questions and comments.

Vaccines tend to be complex products, comprising multiple serotypes of macromolecules and/or bionanoparticles, often with adjuvants. Comprehensive biophysical characterization of vaccine products, and the viruses against which they must raise an immune response, can be challenging. Wyatt Technology’s light scattering toolkit provides a suite of solutions for overcoming many of these challenges, and is employed extensively by virologists as well as vaccine developers in product and process development, process analytics and quality control. 

The toolkit includes: 

  • Size-exclusion chromatography  with multi-angle light scattering (SEC-MALS) and field flow fractionation with multi-angle light scattering (FFF-MALS), which couple online light scattering detectors to separation technologies to determine the molar mass, size, structure, concentration or titer, degree of aggregation and content of each component in solution

  • Dynamic light scattering (DLS), performed directly in microwell plates for high throughput, quantifying size and particle concentration across formulations, processes, serotypes and temperature conditions

  • Real-time MALS or RT-MALS, which monitors molar mass and size in real time as a process analytical tool

  • Concentration-Gradient MALS or CG-MALS, which quantifies protein-protein and protein-nucleic acid interactions, to assess oligomerization as well as mechanisms and affinity of neutralizing antibodies

Speakers: Camille Lawrence, Ph.D., Application Scientist, Wyatt Technology

Dan Some, Ph.D., Principal Scientist, Wyatt Technology

Michelle Chen, Ph.D., Vice-President of Analytical Services, Wyatt Technology

Sophia Kenrick, Ph.D., Director of Analytical Services, Wyatt Technology

Christoph Johann, Ph.D., Global Product Manager, Wyatt Technology

Time and Date: Thursday, May 28, 2020 at 8am CST | 9am JST| 10am AEST

On demand available after airing until May 28, 2021

Sponsor: Wyatt Technology Corp

Register free: http://www.chromatographyonline.com/lcgc_w/biophysical_tools