SEC-MALS Detector
Based on Wyatt Technology?s legacy of multi-angle light scattering (MALS) detectors, the DAWN HELEOS-II is the MALS detector with the greatest sensitivity for absolute molecular weight and size determinations of polymers and biopolymers in solution. The DAWN may be connected in series to any chromatographic system in order to determine absolute molar masses without the use of reference standards or column calibration.
Based on Wyatt Technology’s legacy of multi-angle light scattering (MALS) detectors, the DAWN HELEOS-II is the MALS detector with the greatest sensitivity for absolute molecular weight and size determinations of polymers and biopolymers in solution. The DAWN may be connected in series to any chromatographic system in order to determine absolute molar masses without the use of reference standards or column calibration.
The HELEOS-II may be ordered with precise sample temperature control from –30° C to 150°, or from ambient to 210° C and can be used with virtually any solvent: aqueous or organic. In addition, the instrument has a bright, 64,000 color LCD display that shows current system states, chromatographic conditions, operating status and more. The instrument incorporates a special 120mW gallium arsenide laser operating at a wavelength of 658 nm. This laser, together with its unique optical collimator, produces light-scattering signals superior to those obtained with any other light scattering instrument.
The DAWN HELEOS-II instruments join Wyatt Technology’s unique light scattering systems which include the miniDAWN TREOS, as well as the Optilab rEX—the only refractive index detector available that can be built to operate at any wavelength selected by the customer.
Contact: Geofrey Wyatt
Tel: 805-681-9009
FAX: 805-681-0123
E-mail: info@wyatt.com
Website:www.wyatt.com
Free Poster: NDSRI Risk Assessment and Trace-Level Analysis of N-Nitrosamines
April 25th 2025With increasing concern over genotoxic nitrosamine contaminants, regulatory bodies like the FDA and EMA have introduced strict guidelines following several high-profile drug recalls. This poster showcases a case study where LGC and Waters developed a UPLC/MS/MS method for quantifying trace levels of N-nitroso-sertraline in sertraline using Waters mass spectrometry and LGC reference standards.
New Guide: Characterising Impurity Standards – What Defines “Good Enough?”
April 25th 2025Impurity reference standards (IRSs) are essential for accurately identifying and quantifying impurities in pharmaceutical development and manufacturing. Yet, with limited regulatory guidance on how much characterisation is truly required for different applications, selecting the right standard can be challenging. To help, LGC has developed a new interactive multimedia guide, packed with expert insights to support your decision-making and give you greater confidence when choosing the right IRS for your specific needs.
Using the Carcinogenic Potency Categorisation Approach (CPCA) to Classify N-nitrosamine Impurities
April 25th 2025Learn how to manage nitrosamine impurities in pharmaceuticals with our free infographic. Discover how the CPCA approach establishes acceptable intake limits and guides the selection of NDSRI reference samples. Stay compliant and ensure safety with our ISO-accredited standards.
