Sensitive LC-MS/MS approach for the quantification of proteolysis targeting chimeras in a biological matrix

Key Takeaways

• Personalized treatment strategies have advanced lung cancer brain metastases management, integrating targeted therapies and immunotherapies for improved outcomes.
• Stereotactic radiosurgery and whole-brain radiation therapy are evolving with novel systemic therapies, maintaining their importance in treatment.
• Multidisciplinary collaboration is crucial for optimizing treatment plans, considering genetic mutations, patient performance status, and potential side effects.
• Ongoing research and clinical trials are essential for further progress in managing lung cancer brain metastases.