Liquid chromatography-tandem mass spectrometry (LC-MS/MS) finds high fentanyl levels do not predict toxicity in tolerant users.
|Articles|March 7, 2013
- The Column-03-07-2013
- Volume 0
- Issue 4
Simultaneous Qualitative and Quantitative Proteomics Using Tandem Mass Spectrometry
Quantitative proteomics aims to provide large-scale qualitative and quantitative data about every protein in a biological sample. However, drawbacks associated with current techniques can make it difficult to generate the data required. Research scientists have recently developed a new approach that allows highly multiplexed high-resolution MRM quantitation of most of the detectable proteins in a sample in a single analysis.
Advertisement
Quantitative proteomics aims to provide large-scale qualitative and quantitative data about every protein in a biological sample. However, drawbacks associated with current techniques can make it difficult to generate the data required. Research scientists have recently developed a new approach that allows highly multiplexed high-resolution MRM quantitation of most of the detectable proteins in a sample in a single analysis.
Articles in this issue
over 13 years ago
Market Profile: Market Profile: Solid-Phase Extractionover 13 years ago
Thin layer chromatography detects substandard TB drugsover 13 years ago
Pittcon 2013 Previewover 13 years ago
APIX goes miniatureAdvertisement
Related to this article
Gas chromatography-ion mobility spectrometry (GC-IMS) identifies odor markers that flag early mold growth in cigar tobacco.
Lorna Nisbet from the Leverhulme Research Centre for Forensic Science, discusses a GC–MS. technique developed to detect anabolic-androgenic steroids in e-cigarettes seized from Scottish prisons.
Kinjal Bhatt and Ina Varfaj trace their pull toward analytical science to a saturated chromatography peak and the moment their first chiral peaks separated.
Gérard Hopfgartner explains why pairing SFC with dopant-assisted APPI can match, or even beat, electrospray sensitivity, even at microflow LC rates.
Emma Macturk from LECO Corporation explains which forensic applications benefit from GC×GC’s greater peak capacity, and when the additional separation power may only provide limited benefits.
Koji Yamaguchi of the International University of Health and Welfare (Narita, Japan) discusses a novel derivatized liquid chromatography-tandem mass spectrometry (LC-MS/MS) method plus propofol glucuronide (PRG) marker which improves forensic propofol detection.
Gas chromatography-mass spectrometry (GC-MS) coupled with headspace solid-phase microextraction )HS-SPME) links cocoa variety to chocolate aroma and flavor profiles.
Advertisement
Advertisement
Trending on LCGC International
1
GC-MS Uncovers Cocoa Variety's Chocolate Aroma
2
Using UHPLC-MS/MS to Help Pinpoint Time of Death
3
Peaks & Pioneers: Isabelle Kohler on Life Beyond the Traditional Academic Track
4
Automated Sample Preparation for Oligonucleotide Bioanalysis Using Magnetic SPE
5