News|Articles|September 2, 2025

LCGC Supplements

  • Hot Topics in Gas Chromatography (August 2025)
  • Pages: 12–16

Switching from Helium as a Carrier Gas: Can You Afford Not To?

Switching from helium as a carrier gas is less of a problem than people think. Is it time for you to think about it?

Helium is a non-renewable element formed over billions of years via radioactive decay of Uranium 238, primarily extracted as a byproduct of natural gas via cryogenic distillation. It is indispensable across several sectors, with applications in magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) cooling, as well as lifting gas (balloons and blimps), semiconductors, space applications, welding, and gas chromatography (GC), with chromatographic and spectroscopic uses accounting for approximately 15% of global usage (1). Despite global helium reserves estimated at 31.3 billion m3 (2)—enough for over 180 years at current usage (3)—frequent localized shortages persist, driven not by immediate scarcity but by production issues and geopolitical instability.

Related to this article

Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.