News|Articles|November 2, 2026

Testing Plastic Packaging for PFAS Without SPE: A Fast, Cost-Effective Direct Shoot LC-MS/MS Method on the QSight® 500 System That Meets Regulatory Requirements

PFAS rules now reach the packaging itself. Under the EU Packaging and Packaging Waste Regulation, food contact packaging containing 25 ng/g or more of any individual PFAS cannot be placed on the market, so labs need targeted data at production volume. This application note shows a Direct Shoot LC-MS/MS method on the PerkinElmer QSight 500 system that quantifies 26 PFAS in food packaging bottles, pharmaceutical packaging bottles and packaged drinking water. It uses a simple methanol extraction and no SPE cleanup. Calibration runs from 0.05 to 25 ng/g, with recoveries predominantly within 70 to 130%.


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